Molsid, a Deeptech company, based in Lyon (France), develops a new generation of fluorogenic molecular probes.
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Modern life science and biotech/medtech applications require the detection of the biocatalytic activity of a specific enzyme in live cells without the use of antibodies. However, today’s chromogenic substrates suffer from low detection sensitivity, and marketed fluorogenic substrates are unable to ensure retention of the newly generated fluorescence at the site of the targeted enzyme activity. The use of enzyme-responsive probes releasing a fluorescent precipitate ensures signal retention at the site of the enzyme activity. This, in combination with catalytic signal amplification, delivers a maximum signal-to-noise ratio and thus heretofore unmatched detection sensitivity. This performance helps to clearly and rapidly identify biomarkers for cancer and other pathologies, microbial contaminants, and antibiotic resistance. Antimicrobial Resistance being announced to become the leading cause of death by 2050 world-wide, the need for early diagnostics is becoming more urgent by the day.
In 2003, Jens Hasserodt, professor of chemistry at the University of Lyon – ENS de Lyon, started a research program into the development of a new generation of pro-fluorescent, enzyme-responsive probes that retain the signal at the site of enzyme activity. Today, Molsid owns exclusive licences for the five patent families protecting this innovative molecular technology and currently grows its own patent portfolio.
Many reports over the past 20 years have highlighted the unique properties of the unique solid-state fluorophore ELF97. ELF97 is a highly attractive candidate for the incorporation into enzyme-responsive molecular probes that furnish high sensitivity, rapid response, and signal retention. But ELF97 has unfavourable chemical properties with regard to its incorporation into stable and robust molecular probes. Consequently, only one probe has hitherto been marketed, a probe responding to generic phosphatase activity. It is here that Molsid’s innovative chemical technology changes the game by offering robust probes for many enzyme activities while generating a longlasting, and intensely fluorescent precipitate.
For the first 5 years of incubation on the ENS campus, Molsid’s team had access to high-end instrumentation and top chemistry and biology platforms. We now possess this environment of our own in our new headquarters on the campus of the Biopark Lyon. Here, we are in the process of developing and producing our innovative diagnostic tests with brand-new labs and instruments. Team members comprise highly experienced researchers and engineers from biology and chemistry, a quality project manager and several directors covering corporate strategy, business development, finance, marketing and clinical validation.
Anne Khoschnud
— Chairwoman, Co-founder
25 years of experience in innovative company set-up, business strategy and development, innovation management, team and ressources management, international marketing
After initial linguistic and economic studies in Heidelberg, Germany, Anne got a Master of Project Management from Montpellier University in France. She worked in the Financial Direction of Imerys SA in Paris and in the consumer marketing department of T-Mobile International in London before joining a first start-up project in France. She co-founded 3 innovative companies in different fields (IT, optoelectronics and biomed) and worked as a business strategy consultant for 7 years. She is an occasional lecturer at 2 French top universities (ENSAM, Sorbonne). Anne co-founded Molsid in 2018 and was its CEO & Chairwoman until Oct 2021 before splitting the position and becoming its Chairwoman.
Jens Hasserodt
— Chief scientific advisor, Co-founder
30 years of experience in R&D in organic chemistry, design of molecular probes, inventor of SmartID technology, renowned scientist and lecturer, Professor at ENS Lyon
Jens obtained his PhD degree in Chemistry from Heidelberg University in Germany. He spent 7 years at the Scripps Research Institute in San Diego, CA, before joining France’s elite university Ecole Normale Supérieure in Lyon as a professor of chemistry. Ever since, he developed an international reputation for his research into the detection and characterization of enzyme activity by optical (fluorescence) and magnetic (MRI) detection using sophisticated chemical reactants. He has published over 50 peer-reviewed articles in international science journals, has filed 11 patents, and trained 17 PhD students to date. Jens is Molsid’s Chief Scientific Advisor and its main shareholder.
Stéphane Gavoille
— CEO & Market Access Director
30 years of experience in strategic marketing and business development at VP level positions, working at global level in multinational companies in the field of life sciencesand diagnostic .
Stéphane is French. He holds a Master’s degree in microbiology and immunology and a MBA from ESSEC Business School. 30 years’ experience in biotech marketing, focused on launching innovative solutions in the molecular diagnostics and life sciences research markets. Market development manager at ROCHE Diagnostics, then head of the biotechnology unit at MERCK SIGMA ALDRICH. Former EMEA Marketing VP at BIORAD Laboratories and Actylis.
David Luo
— Chief Financial Officer (part-time)
After having graduated from prestigious Supélec (CentraleSupélec) engineering school in France, David worked initially as IT Consultant for ALTEN, mainly on high-stakes defense communication systems for THALES, before joining SYNOPSYS as Senior Project Manager, working on EDA testing tools. David then founded DEAM, a deep-tech company specializing in human-machine interfaces (HMI), advanced display technologies, and smart lighting solutions. He developed the company several years in Europe and then in China. Over two decades he filled all positions needed to build and scale an international tech venture: CEO, R&D Lead, BD& Strategy, Finance & Operations. Mastering the full lifecycle of a deep-tech startup, from ideation & IP creation to industrial scale-up and global commercialization, he operates today at the side of other founders as part-time C-Level.
Gilles Antoniotti
— Medical Affairs Director
Gilles Antoniotti has 30 years of experience in the health sector.
He has been a Medical Biologist and a medical crisis manager at Nosoconseil RAMSAY SANTE, an Associate professor and researcher at
the Pitié Salpétrière medical school, a founding shareholder of Biomedica which then became
EUROFINS LAB RA, and of NOSOCONSEIL. In France, he is a speaker and a national expert at HAS
(government agency for the evaluation of health technologies), SPF (national health agency), and
Cepias (prevention of infections center), and author of international publications and medical books.
Prof. Rafael Cantón
Clinical Microbiology specialist, Head of the Clinical Microbiology Department at the University Hospital Ramón y Cajal in Madrid (Spain) and associated Professor of Clinical Microbiology at Complutense University in Madrid.
Prof. Rafael Cantóns research activity is developed within the Spanish Network for Research in Infectious Diseases (CIBERINFEC, https://www.ciberinfec.es/) and Institute Ramón y Cajal for Health Research (IRYCIS, http://www.irycis.org) in which he coordinates the Microbiology, Immunology and Infection Area. This activity is focussed on antimicrobial resistance mechanisms, including extended-spectrum beta-lactamases and carbapenemases, antimicrobial susceptibility testing, respiratory tract infections (mainly in bronchiectasis and cystic fibrosis), and interplay of clonal epidemiology and resistance. He is currently the clinical data coordinator of the European Committee for Antimicrobial Susceptibility Testing (EUCAST) (former president). He has been President of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC). He has published more than 600 articles in peer-review journals, 55 book chapters and had several communications on international meeting and congresses. His H factor is 96. He is member of the editorial board of Microbial Drug Resistant, Drug Resistance Updates, Diagnostic Microbiology and Infectious Diseases, Enfermedades Infecciosas y Microbiología Clinica and Revista Española de Quimioterapia journals. He is editor of the Clinical Microbiology Procedures of the SEIMC (https://seimc.org/).
Dr. Beverly Egyir
Senior Research Fellow · Noguchi Memorial Institute for Medical Research (NMIMR), Ghana
Beverly Egyir activities comprise research on AMR, participation in the antimicrobial stewardship, and monitoring of hospital and community-acquired infections. She uses state-of-the-art phenotypic and molecular tools to understand the epidemiology of antimicrobial-resistant bacteria isolated from humans, livestock, and the environment. Specifically, she studies superbugs like methicillin-resistant Staphylococcus aureus (MRSA), ESBL-producing bacteria, and others- with an overall goal of tackling antimicrobial resistance in Ghana and on the African continent. She also teaches and supervises undergraduate and postgraduate students in the field of bacteriology and antimicrobial resistance. She has organized several training sessions for students/ laboratory staff on correct identification and performance of standard antimicrobial susceptibility testing of bacterial species. She founded Women in Biomedicine, Africa, an organization born out of a passion to provide mentorship and career guidance for young women in biomedical careers; to harness their skills to significantly improve health care in Africa. She is a member of the National Antimicrobial Resistance Group in Ghana.
Dr David Jenkins
Medical microbiologist and infection prevention specialist at University Hospitals of Leicester NHS Trust, President of BSAC
David Jenkins has served as lead infection prevention doctor at University Hospitals of Leicester for over 20 years. He is also his Trust’s lead doctor for antimicrobial stewardship. In addition, Dr Jenkins is responsible for undergraduate and postgraduate teaching in infection at the University of Leicester Medical School. He is engaged in research in antimicrobial stewardship and was a co-investigator on an antibiotic prescribing behaviour research project funded by the Economics and Social Research Council, looking at prescribing practice in the UK, South Africa and Sri Lanka. He also took part in a study investigating antimicrobial use and resistance in Cape Verde.
Prof. Frédéric LAURENT
Frédéric LAURENT is Professor of Microbiology at the Faculty of Pharmacy of Lyon within the University Claude Bernard Lyon 1. He leads the Department for bacteriology within of the Hospices Civils de Lyon (HCL)
Prof. Frédéric LAURENT is Professor of Microbiology at the Faculty of Pharmacy of Lyon within the University Claude Bernard Lyon 1. He leads the Department for bacteriology within of the Hospices Civils de Lyon (HCL). Frédéric holds a diploma in Medical Biology and obtained his pharmacy thesis in 1997, a PhD in 2000 and an authorization to supervise research (HDR) in 2005. He completed a post-doctoral fellowship at St George’s Hospital-University of London devoted to the The use of genetic approaches (DNA chips) to understand the pathophysiology of staphylococcal infections. He is co-principal investigator of the “Pathogenesis of staphylococcal infections” team within the International Center for Research in Infectiology INSERM U1111-CNRS UMR5308, University Lyon 1, ENS de Lyon and in charge of a dedicated research axis specifically for understanding the pathophysiology of staphylococcal osteoarticular infections.
He is also co-director of the National Reference Center for Staphylococci, which is the pathogen most frequently involved in osteoarticular infections. He has published more than 200 publications since 1995 as well as numerous book chapters. He is a member of the executive committee of the European Staphylococcal Study Groups (EGES) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID).
Prof. Robin Patel
Robin Patel, M.D., is the director of the Infectious Diseases Research Laboratory. In the research laboratory, she and her colleagues focus on biofilms. Biofilms cause a large number of infections in modern clinical practice, such as prosthetic joint infection and endocarditis.
Prof. Patel is also the chair of the Division of Clinical Microbiology and the director of its Bacteriology Laboratory. In this state-of-the-art clinical facility, she and her colleagues develop and deploy cutting-edge assays for clinical detection of bacteria, identification of bacteria, and characterization of antimicrobial resistance and susceptibility.
Prof. Laurent Poirel
Medical and Molecular Microbiology Unit, Faculty of Science and Medicine, University of Fribourg, Switzerland. Swiss National Reference Center for Emerging Antibiotic Resistance
Prof. Laurent Poirel is Associate Professor at the Emerging Resistance to Antibiotics Research Unit and Swiss National Reference Center for Emerging Antibiotic Resistance at the University of Fribourg. His research interests emerging mechanisms of resistance to ß-lactams, polymyxins, and quinolones in Gram-negative rods, either in human and veterinary medicine. He is specialized on the genetics of acquisition of resistance genes in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii, plasmid-mediated quinolone resistance, and polymyxin resistance determinants in Enterobacteriaceae. He has co-invented a series of rapid diagnostic tests for detection of emerging resistance traits. He is the author of ca. 600 publications in international journals, his H-index being 136. He is the Editor-in-Chief of the European Journal of Clinical Microbiology and Infectious Diseases and Associate Editor of two highly-ranked journals, i.e. Antimicrobial Agents and Chemotherapy and Journal of Antimicrobial Agents. He has been active member of the ESCMID, being a member of the Executive Subcommittee (2015-2018), co-director of two ESCMID Summer Schools (Borstel 2017 and Paris 2018), and currently member of the ESGARS Executive Committee.
Dr. Mandy Wootton
Scientist/Operational manager of the Specialist Antimicrobial Chemotherapy Unit (SACU) in Public Health Wales, a unit providing an antibiotic-resistance reference service to Wales.
Dr. Mandy Wotton has >20 years of experience in susceptibility testing methods and resistance mechanisms. She is secretary of the BSAC susceptibility testing committee, providing educational workshops and conferences and she is an active participant in developing EUCAST methodology and guidelines for the European Development Laboratory (EDL). Prior to her Cardiff position, she spent over 10 years in clinical research on antibiotics in Bristol, where she completed her PhD in glycopeptide resistance in S. aureus.
Bernard Mandrand
— Strategic Advisor
40 years of experience in leading positions in the molecular biology and diagnostics industry.
Bernard holds a PhD in Biophysics and biochemistry from UCB Lyon1 in 1974. Co-founder and Chairman of several companies, Bernard is a former Scientific Director of bioMérieux and Scientific Director of Lyonbiopôle Excellence Cluster in Lyon. He co-founded and led several start-ups and spin-offs: Ademtech, Apibio (a JV between bioMérieux-CEA), Adjuvatis and GlycoBAR. Specialized in bio-analysis and microbiology, he co-authored 68 publications as well as 62 patents granted in Europe and 55 granted in the US. Bernard is a renowned expert for innovation in the life sciences sector. He is Molsid’s Strategic Advisor since its foundation in 2018.
Soizic Ambrosi
— Strategic Advisor
20 years of experience in legal, tax and finance affairs in Pharma
Soizic Ambrosi has filled major positions within big pharma players such as Novartis where she was Head of the Tax department. She is a former member of the Board of Banque de France and LEEM Tax Council. Soizic studied at Harvard Business School Finances and Collège Polytechnique and has a DJCE (legal) diploma. Former CFO of Molsid, and still a shareholder, she founded her own Healthtech start-up recently (Intertio) of which she is the Chairman and CEO.
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